Antitumoral activity of curcumin: an adjuvant therapeutic strategy

Curcumin, an active substance contained in Indian spice called turmeric or curcuma, is well known for its anti-inflammatory and antioxidant properties. In recent times, it was taken into account studied as antitumoral molecule, by relying on interference several biological mechanisms, such the inhibition of inflammatory mediators, enhancement detoxifying enzymes’ action processes cell growth proliferation. Studies show how high dosage curcumin vitro inhibits colorectal tumor cells, pancreatic lung cancer cells glioblastoma’s interfering signaling pathways Wnt/β-catenin, NF-kB PI3K/Akt leading to cycle arrest apoptosis. Furthermore, association between chemotherapeutic agents 5-fluorouracil strengthens drug’s cytotoxicity cells’ susceptibility towards agent.